Treatment of chronic hepatitis B pegylated interferon treatment is the best policy

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According to the Department of Health disease death statistics, there are about seven thousand people died of liver cancer each year, of which 80% of liver cancer and hepatitis B virus infection, Far Eastern Hepatobiliary Hospital Division of Gastroenterology Liang Cheng Chao, MD, B liver virus is mainly through body fluids or blood pathways infection, generally divided into two types of vertical transmission and horizontal transmission. Vertical transmission refers to the mother with the original production process, the hepatitis B virus to the newborn; horizontal transmission is through blood or body fluids containing the virus, enters the body through blood or infected wound, a common mode of infection, such as blood transfusion, sharing needles, piercing, tattoo, tattoos, sharing a toothbrush or razor, sexuality and so may be infected. Taiwan now adult hepatitis B carrier rate as high as 15% to 20%, indicating that hepatitis B prevention is worth people pay attention, if accidentally infected hepatitis B, there are oral antiviral interferon and choose to seize early detection of early treatment principle is is the best policy!
Liang PHYSICIAN, B liver infection can be divided into three natural course first stage, called "immune tolerant phase," during this period a large number of virus replication in the liver cells, it can be measured in serum high concentrations of hepatitis B virus volume (HBV DNA) and hepatitis B e antigen (HBeAg)-positive, because the lack of effective antiviral host response, no clinical symptoms, liver biopsy is almost no or only mild inflammation, serum amino acid converting enzyme (ALT or GPT ) is normal, this stage often lasted for decades and require no treatment intervention. The second phase is called "immune clearance phase", until the patient to young period, this period of the host immune system to attack viruses, cytotoxic T lymphocytes attack was hepatitis B virus infected liver cells, causing liver cell necrosis, thus serum ALT values ​​have increased, this time the amount of hepatitis B virus and hepatitis B e antigen concentration will decrease, patients have different degrees of clinical symptoms, some patients need to consider this treatment period, but the duration of this phase is also more complex, can be sustained ranging from several months to several years, regular follow-up treatment, has become another focus. The third stage is called the period of inactivity, normal serum ALT values, e antigen-negative, e antibody-positive, HBV DNA is embedded in the DNA of liver cells; liver biopsy may show slight variations or inactive hepatitis.
Currently hepatitis B treatment in two ways, one is oral antiviral drugs, patients need daily doses, lowering viral load results quickly, but certain drugs prone to drug resistance, a high risk of recurrence after stopping; Another is long- interferon therapy, interferon regulate the immune system and fight the virus two characteristics, there is no resistance, and the treatment course clear that the current NHI provides interferon therapy treatment for six months to a year, of which e antigen-positive patients required Continuous injections for 24 weeks negative patients are injected with 48 weeks.
Dr Leung said even after discontinuation of interferon therapy, treatment will continue for the role, so there is a higher chance to reach the target surface antigen disappeared, according to research data shows, e antigen-negative patients with interferon treatment, discontinuation track to the fifth year, there are 12% of the patients surface antigen disappeared, as e antigen-positive chronic hepatitis B patients with pegylated interferon for 48 weeks, at 6 months after completion of treatment, 36% to reach serum e antigen seroconversion, It is therefore recommended in patients with chronic hepatitis B can discuss with your doctor whether it is suitable priority to the pegylated interferon treatment.